Sassuolo sacked Alberto Aquilani on Monday, becoming the sixth Serie A club already this season to dismiss their head coach following a difficult start to the campaign.
Aquilani only lasted 13 matches in charge having been appointed in the close-season, after a run of five straight defeats left Sassuolo 17th in the Italian top-flight table and just one point above the relegation zone.
"Sassuolo Calcio announce that Alberto Aquilani has been relieved of his duties as (the) first team's coach, along with his staff," the club said in a brief statement, two days after a 3-0 loss at Roma.
Former Liverpool, Roma and Italy midfielder Aquilani was given the job after leading Catanzaro to the Serie B play-offs last season.
He follows in the footsteps of a slew of Serie A coaches to lose their jobs this term, kicked off by Fabio Grosso's sacking by Fiorentina just three games into the campaign.