Mason Greenwood scored as Marseille strolled to a 6-0 win over third-tier Bourg-Peronnas in the French Cup last 64 on Sunday, while Monaco edged an all-Ligue 1 tie with Auxerre.
Captain Leonardo Balerdi put Marseille ahead before Greenwood struck on the hour as Roberto De Zerbi's side turned the screw in the final 30 minutes.
Pierre-Emile Hojbjerg, Igor Paixao, Bilal Nadir and teenager Tadjidine Mmadi were also on target for 10-time winners Marseille, who last lifted the French Cup in 1989.
"It wasn't perfect but it was a good match," said De Zerbi.
"It was only 1-0 at halftime and the cup can throw up some nasty surprises. I was fearing this match but we had the right approach."
Danish forward Mika Biereth netted both goals as Monaco saw off Auxerre 2-1, with Strasbourg beating second-division Dunkerque by the same scoreline.
Troubled Nice ended a run of nine successive defeats with a 2-1 victory over Ligue 2 promotion chasers Saint-Etienne, while Nantes won 5-3 away to third-tier Concarneau.