Manchester City will face Real Madrid for the 16th time in the UEFA Champions League (W5 D5 L5), twice as often as they have faced any other team in the competition (Bayern Munich - 8). This will be the first time two teams have met in the knockout phase of the competition in five consecutive seasons.

Only Bayern Munich (8) and Juventus (7) have won more UEFA Champions League games against Real Madrid than Manchester City (5), who beat them 2-1 in this season's league phase.