Bayer Leverkusen have progressed from four of their five major European knockout ties against English clubs, failing only against Liverpool in 2004-05 in the UEFA Champions League. Arsenal's only previous European meetings with Bayer Leverkusen came in the second group stage in 2001-02, drawing 1-1 away and winning 4-1 at Highbury.

Arsenal's only previous European meetings with Bayer Leverkusen came in the second group stage in 2001-02, drawing 1-1 away and winning 4-1 at Highbury.